A previous review found that taking CBD with antihypertensive medications can change the blood concentration of either substance. If a person uses CBD and blood pressure medications, they should inform their doctor. A person can test positive for THC, an active ingredient in cannabis. Researchers have found that CBD can lower blood pressure, which may be a cause for concern for people taking medications for high blood pressure.
Taking CBD with blood pressure medications could cause low blood pressure, fainting, and falls. People taking medications for high blood pressure, such as ACE inhibitors, beta-blockers, or diuretics, may need to control their blood pressure while using CBD. The CBD Project found that cannabidiol can interact with other medications by inhibiting cytochrome P450 activity. Cytochrome P450 is a family of liver enzymes that metabolize most of the drugs we use.
CBD can deactivate cytochrome P450 enzymes at a specific dose for a short period of time, preventing us from metabolizing certain compounds. In addition, these enzymes could also deactivate cannabidiol.
